Women report experiencing pain more frequently than men, according to a global analysis drawing on data from more than six million people. The study, published in Nature Medicine, offers some of the most comprehensive evidence yet that the burden of pain is not distributed evenly — and that the difference is too large and too consistent to dismiss as chance.

The research also challenges a common assumption about how pain changes with age. Rather than rising steadily throughout life, reports of pain appear to climb most sharply before the age of 55, after which the pattern becomes more complex. The findings raise pressing questions about why women bear a heavier load of pain, pointing to a mix of biological, hormonal, psychological and social factors, including the possibility that women's symptoms are taken less seriously by clinicians. Understanding these disparities is a first step toward fairer, more effective care for everyone who lives with persistent pain. The researchers argue that closing the gap will require clinicians to take women's reports seriously from the outset, and health systems to collect and publish the data that exposes where care diverges.